Dineo Khabele, MD, chair of Department of Obstetrics & Gynecology, works in her lab on December 27, 2022. MATT MILLER/WASHINGTON UNIVERSITY SCHOOL OF MEDICINE

Dr. Khabele’s research laboratory uses a bi-directional translational research approach to develop novel drug combinations to treat ovarian cancer. Her lab group uses de-identified clinically annotated tissue samples and patient-derived xenograft models to validate molecular biomarkers and confirm mechanistic results for further testing in the clinic.

We utilize established cell-based and mouse models, functional genomics, transcriptomics, and proteomics to investigate the following focus areas:

  • Epigenetic drug regimens for treating chemotherapy-resistant ovarian cancer
  • Targeting macrophages in the ovarian tumor microenvironment