Prabagaran Esakky

Prabagaran Esakky, PhD

Instructor in Ob & Gyn

Phone314-362-1997

Emailesakkyp@wudosis.wustl.edu

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Education

  • BSc, Zoology, Chemistry and Botany: Sri Paramakalyani College, MS University, India (1995)
  • MSc, Microbiology: Sri Paramakalyani College, MS University, India (1997)
  • PhD, Biochemistry: NIRRH, University of Mumbai, India (2007)
  • Postdoctoral Fellowship, Neurobiology: Walter and Eliza Hall Institute, Melbourne, Australia (2009)
  • Postdoctoral Fellowship, Physiology: University of Tennessee Health Science Center, Memphis, TN (2010)
  • Postdoctoral Fellowship, Ob & Gyn: Washington University, St. Louis, MO (2015)

Recognition

Memberships:

Indian Society for the Study of Reproduction and Fertility
Society of Toxicology
American Society of Andrology

 

Research Interests

Dr. Esakky’s research work primarily focuses on unraveling the harmful effects upon paternal exposure to environmental pollutants and germ cell toxicants such as constituents of cigarette smoke and viral pathogens like ZIKA on male fertility, male germ cell development, and birth defects in embryos and offspring. As a male reproductive biologist, he is interested in understanding the response of male reproductive system at molecular and cellular levels towards germ cell toxicants and the resultant phenotype in father and their offspring. He employs various experimental approaches including in vitro cell culture system, in vivo male mouse models, and ex vivo testicular organ culture setup in the effort to uncover and minimize the impact of male reproductive toxicants.

The main goal of his studies is two-fold:
1. to address the paternal contribution to reproductive dysfunction and subsequent developmental defects in the offspring; and
2. to identify, and develop a reliable therapeutic biomarker to help in disease prognosis and treatment