Dr. Mysorekar’s work encompasses studies of mechanisms underlying biology and pathophysiology of the urinary bladder to studies of novel infectious etiologies for premature birth. We use mouse models, cell culture models, and conduct translational studies using human placental tissues to ask the key questions:
How does the bladder tissue regenerate upon injury, especially injury caused by uropathogenic E. coli (UPEC) bacteria during an urinary tract infection (UTI)
- UTIs are common and frequently recurrent. What is the mechanism underlying UPEC persistence and re-emergence to cause recurrent UTIs
- Preterm birth (PTB) is common and commonly associated with infection but etiology is unknown. Who causes infection-induced PTB and how?
Our work in the bladder and placenta is laying the groundwork for:
a) cellular mechanisms and molecular regulators that govern the normal rapid, injury-induced regenerative response of otherwise quiescent urothelial stem cells and to apply what we learn about the normal mechanisms to shed light on the disease processes with abnormal urothelial turnover (e.g. recurrent UTIs, interstitial cystitis/painful bladder syndrome, bladder cancer) and
b) uncovering new insights into pathogens involved in PTB and host-pathogen interactions at this mucosal lining, and thereby lead to targeted therapeutic strategies to reduce PTB incidence.
- Urothelial stem cell regeneration
- Augophagy and pathogenesis of UTIs
- Interleukin-6 and aging
- Infection and pre-term birth
- Zika virus infection