Stimulating Uterine Contractility by Oxytocin

This project contributes to improving reproductive health by focusing on a new ion channel and its modulation and how it may help keep the uterus relaxed during the progression of pregnancy. Understanding the expression and activity of this channel may contribute knowledge as to how normal labor proceeds. Once we ascertain this information, we envision that we can better understand how certain pathophysiological conditions such as preterm labor and post-term labor occur. In the muscle layer of the uterus, expression or activity of K+ channels regulate uterine contractions and promote uterine quiescence. Knowledge gained from this proposal will help determine whether this novel K+ channel can modulate uterine function.